Welcome to the project page for the Trans-Proteomic Pipeline (TPP).

The TPP is a complete and mature suite of free and open-source software tools for MS data representation, MS data visualization, peptide identification and validation, protein identification, quantification, and annotation, data storage and mining, and biological inference.

The TPP is available on Linux and Windows systems and builds on Mac OS X as well, and supports a well-established worldwide user community.

More information

 Latest Version

The latest TPP version is 7.0.0, released March 2024.

Read the Release Notes and Installation Notes for the latest version.

Download directly from Sourceforge.

Please reference the following publication when using TPP in your work:

Trans-Proteomic Pipeline: Robust Mass Spectrometry-Based Proteomics Data Analysis Suite
Eric W. Deutsch, Luis Mendoza, David D. Shteynberg, Michael R. Hoopmann, Zhi Sun, Jimmy K. Eng, and Robert L. Moritz
Journal of Proteome Research 2023 22 (2), 615-624
DOI: 10.1021/acs.jproteome.2c00624

To cite other TPP components, please refer to this page.


Development of the TPP was most recently supported by the National Institute Of General Medical Sciences of the National Institutes of Health under award number R01GM087221.

 Related Projects
A set of tools to index and map peptides to proteome databases, including PEFF modifications